Archive
Every issue ever sent, and every one of them still on the record. The generator reads this page before it writes tomorrow's — so no paper, no pearl, no pharmacology fact ever gets a second run. It has a very long memory and absolutely no sentimentality about it.
41 issues · nothing repeated · get the next one
September 2026
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No. 041 Mon · Sep 7
Trends in the Prevalence and Severity of Alcohol and Cannabis Use Disorders Among US Adults
AlsoPersonalized and Optimal Treatment Estimated by a Value-Search Method in a Randomized Clinical Trial With Psychodynamic Versus Cognitive Behavioral Therapy for Depression
PearlIntrojective and Anaclitic Depression Aren't the Same Illness psychodynamic
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No. 040 Sun · Sep 6
Impact of Vagus Nerve Stimulation on Suicidal Ideation in Markedly Treatment-Resistant Major Depression: A RECOVER Study Report
AlsoAcute Effects of Cannabis Inhalation on Cardiac Ectopy, Physical Activity, Sleep, and Glucose
PearlNot All Validation Is the Same Intervention dbt
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No. 039 Sat · Sep 5
Decades After the NIH Revitalization Act: Persistent Gaps in Diversity of US Antidepressant Trials
AlsoTherapist Intrapersonal Factors and Rupture Repair: Professional Self-Doubt, Self-Compassion, and Repair Strategies in a Simulated Cultural Rupture Task
PearlFollow the affect, not the agenda tfp
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No. 038 Fri · Sep 4
Obstetric Risk Associated With Stimulant Versus Nonstimulant Treatment During Pregnancy
AlsoEvaluation of Interventions for Cognitive Symptoms in Long COVID: A Randomized Clinical Trial
PearlNegative capability is a discipline, not a delay psychodynamic
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No. 037 Thu · Sep 3
Open Dialogue versus treatment as usual for adults presenting in crisis to mental health services in England (the ODDESSI Trial): a multisite cluster-randomised trial
AlsoPrediction in routine care: a naturalistic comparison of clinicians and a machine learning model for patients receiving treatment for generalised anxiety disorder
PearlHabituation was never the mechanism — expectancy violation is cbt
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No. 036 Wed · Sep 2
The Typology of Common Psychiatric Disorders as Depicted by Genetic Maps: A Study Based on Swedish Population-Based Registers
AlsoSuicidality at Epilepsy Diagnosis and Future Treatment Resistance in Adults With Focal Epilepsy
PearlGuided discovery only works if you don't already know the destination cbt
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No. 035 Tue · Sep 1
Brain Morphology Mediators of the Association of Childhood Trauma With Bipolar Disorder: An International ENIGMA Bipolar Disorder Working Group Study
AlsoEffectiveness of Atypical Antipsychotic Drugs in Patients with Alzheimer's Disease (CATIE-AD)
PearlThe selected fact turns noise into a session psychodynamic
August 2026
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No. 034 Mon · Aug 31
Life's Essential 8 Cardiovascular Health and Suicide Mortality: Findings From a Nationally Representative Cohort in South Korea
AlsoObsessive-Compulsive Personality Disorder in Radically Open Dialectical Behavior Therapy for Treatment-Refractory Depression
PearlApparent competence: the DBT skill that fools everyone in the room dbt
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No. 033 Sun · Aug 30
Risk of Presentation for Sexual Abuse After a First Emergency Department Presentation for Self-Harm in Childhood or Adolescence
AlsoThe Effects of Antidepressants on Cardiometabolic and Other Physiological Parameters: A Systematic Review and Network Meta-Analysis
PearlIdentification with the aggressor psychodynamic
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No. 032 Sat · Aug 29
Time Trends in Maternal Attention-Deficit/Hyperactivity Disorder and Medication Use in Pregnancy
AlsoMechanisms of Change in the Treatment of Major Depressive Disorder with Metacognitive Therapy and Behavioral Activation — A Random Intercept Cross-Lagged Panel and Mediation Analyses
PearlReverie isn't empathy -- it's digestion psychodynamic
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No. 031 Fri · Aug 28
Use and Misuse of GLP-1 Receptor Agonists Among People With Eating Disorders
AlsoDepression and Anxiety Associate With Adverse Cardiovascular Events via Neural, Autonomic, and Inflammatory Pathways
PearlSymbolic equation: when the metaphor stops being a metaphor psychodynamic
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No. 030 Thu · Aug 27
Integrated mental health treatment and employment services for refugees with PTSD: randomised controlled trial
AlsoIntegrated therapist and online cognitive behavioural therapy in addition to usual care versus usual care for depression in primary care in England (INTERACT): a two-group, parallel, multicentre, randomised controlled trial
PearlOptimal frustration is not empathic failure — it's how structure gets built psychodynamic
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No. 029 Wed · Aug 26
Association of Lithium Use With Suicide and Self-Harm Among Chinese Adolescents and Adults With Bipolar Disorder: A Nationwide Multicenter Retrospective Cohort Study
AlsoAnticholinergic Drug Burden and Incident Cardiovascular Events: A Population-Based Study
PearlSplitting doesn't stay in the room — it recruits the whole team tfp
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No. 028 Tue · Aug 25
Psychological and Psychosocial Interventions for People With Schizophrenia and Co-Occurring Substance Use Disorders: A Systematic Review and Meta-Analysis
AlsoPatients' Perspective on an Optimal Therapeutic Alliance; Facilitating Engagement in Treatment of Antisocial Personality Disorder
PearlThe downward arrow finds the belief the thought record can't touch cbt
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No. 027 Mon · Aug 24
Connectivity- vs Scalp-Based Targeting of Accelerated Transcranial Magnetic Stimulation for Depression: A Randomized Clinical Trial
AlsoA 14-Month Randomized Clinical Trial of Treatment Strategies for Attention-Deficit/Hyperactivity Disorder. The MTA Cooperative Group. Multimodal Treatment Study of Children with ADHD
PearlContract-setting is the intervention before the interpretation tfp
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No. 026 Sun · Aug 23
Pharmacological interventions for ADHD: a systematic review and dose-effect network meta-analysis
AlsoAssessment of adverse effects attributed to statin therapy in product labels: a meta-analysis of double-blind randomised controlled trials
PearlHolding is a technique, not the absence of one psychodynamic
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No. 025 Sat · Aug 22
Electroencephalography Microstate Instability and Clinical Outcomes in Individuals at Clinical High Risk of Psychosis
AlsoThe Significance of Personality Disorder and Traits in Short-Term Psychodynamic and Cognitive Behavioral Therapy for Major Depression
PearlHypermentalizing is confident, articulate, and wrong mbt
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No. 024 Fri · Aug 21
Nationwide Transdiagnostic Age and Sex Patterns in Mental Disorder Disease Development
AlsoCognitive Rehabilitation and Functional Outcomes in Long COVID–Related Cognitive Impairment: A Randomized Clinical Trial
PearlWithdrawal ruptures and confrontation ruptures need opposite repairs psychodynamic
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No. 023 Thu · Aug 20
Effects of Brexpiprazole on Functioning in Patients With Schizophrenia Who Have Hostility and Agitation Symptoms: Post Hoc Analysis of Short- and Long-Term Trials
AlsoEffects of Perceived Working Alliance Quality and Congruence on Naturalistic Psychotherapy Outcome: A Response Surface Analysis
PearlIrreverence is a calculated destabilization, not sarcasm dbt
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No. 022 Wed · Aug 19
Adjunctive Antipsychotics in Major Depressive Disorder: A Systematic Review and Network Meta-Analysis
AlsoRehospitalization as a Mediator of the Association of Postoperative Delirium With Cognitive Decline in Older Adults
PearlThe therapist's survival is the intervention — not the interpretation of the attack psychodynamic
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No. 021 Tue · Aug 18
Evaluating Reduced Use and Abstinence as Outcomes in Pharmacotherapy Trials for Stimulant Use Disorder: A Meta-Analysis of 12 Randomized Controlled Trials
AlsoPredicting Premature Treatment Termination in Inpatient Psychotherapy: A Machine Learning Approach
PearlActivate the here-and-now before you illuminate it — reversing the order wastes the data group
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No. 020 Mon · Aug 17
Optimising and Personalising Task-Shared Psychosocial Interventions for Common Mental Disorders: A Bayesian Component Network Meta-Analysis of Individual Participant Data
AlsoLithium Plus Valproate Combination Therapy versus Monotherapy for Relapse Prevention in Bipolar I Disorder (BALANCE): A Randomised Open-Label Trial
PearlMarked mirroring is what builds affect regulation — not validation itself mbt
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No. 019 Sun · Aug 16
Connectivity- vs Scalp-Based Targeting of Accelerated Transcranial Magnetic Stimulation for Depression: A Randomized Clinical Trial
AlsoAntidepressant Treatment Duration and Risk of Sudden Cardiac Death: A Nationwide Cohort Study
PearlEpistemic trust is what determines whether insight travels home mbt
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No. 018 Sat · Aug 15
Divergent Patterns of Genetic Overlap Between Severe Mental Disorders and Metabolic Markers
AlsoEngage & Connect psychotherapy improves social reward responsivity and reduces postpartum depression
PearlPretend mode isn't insight — it's mentalizing about nothing mbt
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No. 017 Fri · Aug 14
Cognitive, Electrophysiological, and Behavioral Presentation of First-Episode Psychosis With or Without Cannabis Exposure
AlsoImplications of the 2026 Dyslipidemia Guideline for Primary Prevention Statin Therapy
PearlGuilt replacing blame is the signal, not a symptom to fix psychodynamic
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No. 016 Thu · Aug 13
Mirtazapine for Methamphetamine Use Disorder: A Randomized Clinical Trial
AlsoMechanisms of Change in Day Treatment Group Schema Therapy for Severe Personality Disorders: A Multiple Baseline Single-Case Study
PearlIn TFP, naming the dyad is the intervention — not just diagnosing splitting tfp
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No. 015 Wed · Aug 12
Adolescent Mental Health Care and Stigma: The ARTEMIS Randomized Clinical Trial
AlsoAdjunctive Fecal Microbiota Transplantation for Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial
PearlOpposite action for shame only works after you've sorted justified from unjustified dbt
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No. 014 Tue · Aug 11
Semaglutide and Effort-Based Decision-Making in Major Depressive Disorder: A Randomized Clinical Trial
AlsoTesting the Alliance Rupture Repair Model on Two Cases with Successful and Unsuccessful Rupture Repair: A Task Analytic Validation Study
PearlYour countertransference is either standing with the patient or standing in for someone else psychodynamic
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No. 013 Mon · Aug 10
Screening-to-Intervention Pathway for Child Anxiety Problems Alongside Usual School Practice Versus Usual School Practice Only (iCATSi2i): A Cluster-Randomised, Controlled Trial in Primary Schools in England
AlsoCognitive-Behavioral Therapy, Imipramine, or Their Combination for Panic Disorder: A Randomized Controlled Trial
PearlDefusion doesn't argue with the thought — it changes what the thought is made of act
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No. 012 Sun · Aug 9
Antipsychotic Efficacy and Safety of LB-102 in the Treatment of Adults With Acute Schizophrenia: A Randomized Clinical Trial
AlsoNeuropsychiatric Outcomes With Tirzepatide, Semaglutide, and Other GLP-1 Receptor Agonists
PearlTriangulation isn't the problem — it's the map of who's not differentiated family
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No. 011 Sat · Aug 8
Intermittent Theta Burst Stimulation of the Dorsomedial Prefrontal Cortex and Expectancy-Driven Placebo Mood Effects: A Randomized Clinical Trial
AlsoEffects of Short-Term Versus Long-Term Mentalization-Based Therapy on Psychiatric Symptoms in Outpatients With Borderline Personality Disorder: Exploratory Results From a Randomized Clinical Trial
PearlWorking through is not an insight — it's tolerating the same person being good and disappointing, over and over psychodynamic
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No. 010 Fri · Aug 7
Circadian Rhythm Stabilization App to Prevent Mood Episode Recurrence in Patients With Mood Disorders: A Multicenter, Double-Blind, Sham-Controlled, Randomized Clinical Trial
AlsoProlonged Short Sleep and Its Effect on Body Weight and Composition: A Pooled Analysis of Randomized Trials
PearlIn IPT, the problem area you choose is the treatment — pick the wrong one and the technique stops working ipt
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No. 009 Thu · Aug 6
Low-Dose Buprenorphine Following Ketamine Treatment for Suicidal Ideation in Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial
AlsoDialectical Behavior Therapy vs Schema Therapy for Patients With Borderline Personality Disorder: The BOOTS Multicenter Randomized Clinical Trial
PearlAnalyze the retreat, not the thing retreated from psychodynamic
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No. 008 Wed · Aug 5
The Efficacy and Safety of Cannabinoids for the Treatment of Mental Disorders and Substance Use Disorders: A Systematic Review and Meta-Analysis
AlsoMultidomain Lifestyle Intervention for the Prevention of Cognitive Decline in At-Risk Older Adults in Latin America (LatAm-FINGERS): A Single-Blind, Multicentre, Randomised Controlled Trial
PearlNeutrality is not a flat affect — and the real relationship is not a lapse in technique psychodynamic
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No. 007 Tue · Aug 4
Interleukin 6 as a Treatment Target for Depression: A Proof-of-Concept Randomized Clinical Trial
AlsoBaseline Social Inhibition and Age as Moderators of the Within-Patient Alliance-Outcome Link in Treatments for Depression
PearlA behavioral experiment that cannot fail has not tested anything cbt
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No. 006 Mon · Aug 3
Mapping 2-Year Psychiatric and Neurologic Risks After Infections Across Body Systems and Age Groups
AlsoCeperognastat in Early Symptomatic Alzheimer Disease: A Randomized Clinical Trial
PearlThe negative therapeutic reaction: when getting better is the threat psychodynamic
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No. 005 Sun · Aug 2
Personalized fMRI-Guided TMS Targeting the Threat Neurocircuitry in PTSD: A Randomized Clinical Trial
AlsoSession-Level Emotional Processing and Subsequent Somatic Symptom Change in Online ISTDP for Treatment-Resistant Somatic Symptom Disorder: A Lagged Within-Person Secondary Analysis
PearlPsychic equivalence is not a metaphor problem — it is why your reassurance made things worse mbt
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No. 004 Sat · Aug 1
Oral Semaglutide for Alcohol Use Disorder: A Randomized Clinical Trial
AlsoPatient-Centered Prescription Opioid Tapering Methods: A Randomized Clinical Trial
PearlEnactments are not mistakes you avoided badly — they are the material arriving in the only form it can take psychodynamic
July 2026
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No. 003 Fri · Jul 31
Confirmatory Efficacy and Safety Trial of Magnetic Seizure Therapy versus Right Unilateral Ultra-Brief Electroconvulsive Therapy in Depression (CREST-MST): A Randomised, Double-Blind, Non-Inferiority Trial in Canada and the USA
AlsoEmbodied Movement Markers of Alliance Ruptures in Psychotherapy: A Machine Learning Study
PearlBehavioral chain analysis is not a history — it is a search for the link you can actually change dbt
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No. 002 Thu · Jul 30
Clozapine After 1 Failed Antipsychotic Drug Trial in First-Episode Psychosis: A Randomized Clinical Trial
AlsoVenous Thromboembolism After Mechanical Restraint in Psychiatric Hospitals: Population Based Cohort and Self-Controlled Case Series Study
PearlClarification, confrontation, interpretation — the sequence is the technique tfp
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No. 001 Wed · Jul 29
Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression: The EPISODE Randomized Clinical Trial
AlsoPhase 3 Trial of Semaglutide in Metabolic Dysfunction–Associated Steatohepatitis (ESSENCE)
PearlProjective identification, and what containment actually requires of you psychodynamic